China (Mainland)
INCB 024360 CAS NO.1204669-58-8
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Keywords
- 1204669-58-8
- INCB 024360
- 99%
Quick Details
- ProName: INCB 024360
- CasNo: 1204669-58-8
- ProductionCapacity: Metric Ton/Day
- Purity: 98
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Superiority
NCB 024360 is a potent and novel indoleamine-2,3 dioxygenase (IDO)inhibitor with an IC 50 value <100 nM.
IC50 Value: <100 nM [1]
Target: Indoleamine-2,3-dioxygenase
IDO is an immunomodulatory enzyme produced by some alternatively activated macrophages and other immunoregulatory cells (also used as an immune subversion strategy by many tumors). Interferon-gamma has an antiproliferative effect on many tumor cells and inhibits intracellular pathogens such as Toxoplasma and chlamydia, at least partly because of the induction of indoleamine 2,3-dioxygenase.